The Hotel El Señorial is located only a hundred yards away from the shores of the Caribbean Sea, directly in front of the Eugenio María de Hostos Park, Hostos Park, one of the oldest in the city, and only 10 minutes away from Santo Domingo's fabled Colonial Zone. The Hotel is also near several health and beauty clinics, dentists' centers, discos, night clubs and restaurants. The Hotel El Señorial is visited frequently by guests from many of the neighboring islands including Puerto Rico, Aruba, and Curacao and is a favorite of Florida's Cuban community. Additionally, in the December-May period, it is frequented by many European tourists. The family-style hospitality is well-appreciated by the guests, many of whom have come to make it their second home.

The Hotel El Senoral has 22 rooms for 1 or 2 beds, all equipped with air conditioning, cable TV, telephone, hot water, hair dryer, fridge and mini safe.